Company overview:
1910 Genetics is the only company that has built a synergistic,
dual-purpose small and large molecule platform that integrates artificial intelligence (AI),
computation, and biological automation to design drug-like molecules better, faster, and cheaper than traditional approaches.
Based in the Seaport District of Boston, 1910 Genetics is a Series A stage biotechnology startup that was founded in 2018
and is backed by prestigious investors, including M12-Microsoft’s Venture Fund, Sam Altman – the CEO of OpenAI (makers of ChatGPT),
Playground Global, Y Combinator, New Ventures Funds (Scientia Ventures), and many others.
At 1910 Genetics, we first established an understanding of the molecular basis of disease to the granularity at
which the world understands sickle cell anemia. This understanding centers biology as our North Star and drives
our integration of artificial intelligence (AI), computation, and biological automation to accelerate the design
of small molecule and protein therapeutics.
Recent advances in computational technologies have placed historically
“undruggable” targets within therapeutic reach. But at 1910 Genetics,
we often say “Biology is King,” meaning that computational technologies
are only impactful in drug discovery when driven by experimental biology.
Our platforms’ scale and breadth empower us to be therapeutic area-agnostic
with programs ranging from neuroscience and immunology to infectious disease
and oncology, to name a few.
You are someone we can count on to...
- Execute experiments effectively and efficiently
Your key responsibilities will include…
- Executing high throughput screening (HTS) assays in strict accordance with the NIH NCATS Assay Guidance Manual
- Developing and validating HTS biochemical assays for characterizing the activity and selectivity of potential drug candidates
- Developing and validating HTS cell-based assays for characterizing the activity, selectivity, and cellular permeability of potential drug candidates
- Performing a wide variety of experiments across molecular biology, cell biology, biochemistry, in vitro pharmacology, and in vivo pharmacology
- Rigorously documenting all experimental procedures, data, results, manuals, etc. in an electronic laboratory notebook (eLN)
- Leveraging internal and external personnel to troubleshoot experiments
- Effectively communicating research results both verbally and orally
- Managing all external CRO relationships, and cross-checking externally generated results with internal references and/or expectations
- Managing all aspects of lab operations such as ordering, organizing, and restocking reagents, equipment, and other supplies
Ideally, you have…
- B.S. or M.S. in Biology, Cell Biology, Molecular Biology, Biochemistry, Pharmacology, or equivalent
- 0 – 3 years of laboratory experience in an industrial or academic setting
- Experience with or exposure to HTS assays
You will learn…
- Computational and Medicinal Chemistry
- AI/ML applied to drug discovery
You will teach…
- The NIH NCATS Assay Guidance Manual and HTS success criteria to your cross-disciplinary colleagues from Medicinal Chemistry, Computational Chemistry, AI Research, and Machine Learning Engineering
Compensation & benefits
- Extremely generous equity package coupled with competitive salary
- Healthcare benefits
- Generous vacation and parental leave
- Super cool team building activities
- Flexible work schedule
- Great colleagues